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Synthesis, characterization and antibacterial properties of chitosan/Ag2S/CQDs hydrogel

Hongxia Li, Yongdong Liu, Xiang Gao, Xiaohui Niu, Haiyan Fan, and Kunjie Wang

College of Petrochemical Technology, Lanzhou University of Technology, Lanzhou, China

 

E-mail: wangkj80@163.com

Received: 3 June 2022  Accepted: 2 September 2022

Abstract:

Using chitosan as raw material, a composite-featured chitosan/Ag2S/carbon quantum dot (CS/Ag2S/CQDs hydrogels) was synthesized by successfully uploading carbon quantum dots (CQDs) and silver sulfide (Ag2S). According to the SEM and TEM characterization of the material, the hydrogel material has a rich pore-like structure, which can absorb wound tissue fluid and promote wound healing. Staphylococcus aureus (Gram-positive), Escherichia coli (Gram-negative) and methicillin-resistant Staphylococcus aureus were used as model bacteria to test the antibacterial effect of CS/Ag2S/CQDs. This material not only has excellent inhibitory effect on common bacteria (the inhibitory rate of E. coli and S. aureus is 86% and 67%, respectively), but also has good inhibitory effect on drug-resistant bacteria (the inhibitory rate of MRSA is 73%). The bacterial toxicity test showed that CS/Ag2S/CQDs hydrogel had low toxicity. Meanwhile, CS/Ag2S/CQDs hydrogels degraded 28.39% of the hydrogels during a 7 days biodegradation. Its excellent bacteriostatic and degradable properties make it a potential candidate for a new type of medical dressing for clinical application.

Keywords: Chitosan; Hydrogels; Carbon quantum dots; Ag2S; Antibacterial agent

Full paper is available at www.springerlink.com.

DOI: 10.1007/s11696-022-02470-z

 

Chemical Papers 77 (1) 207–217 (2023)

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