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Carboxymethyl cellulose-coated HKUST-1 for baclofen drug delivery in vitro

Hafezeh Nabipour, Mojtaba Mansoorianfar, and Yuan Hu

State Key Laboratory of Fire Science, University of Science and Technology of China, Hefei, People’s Republic of China

 

E-mail: ha.nabipour@gmail.com

Received: 28 February 2022  Accepted: 11 June 2022

Abstract:

Metal–organic frameworks are the new type of crystalline porous materials with specific properties such as appropriate catalytic activity, accessible surface area, tunable pore structure, as well as stable chemical and thermal properties. In this study, solvothermal preparation of a copper-metal organic framework (HKUST; Hong Kong University of Science and Technology) was used to load baclofen as a model drug. Baclofen-HKUST-1 was employed to increase the drug release controllability of bio-polymeric carboxymethyl cellulose (CMC) hydrogel under the gastrointestinal tract (GIT). Results from in vitro drug delivery and kinetic assessments revealed that CMC/baclofen-HKUST-1 bio-nanocomposite could better act against stomach pH; it also increased the releasing homogeneity and drug delivery under GIT conditions. Also, MTT assay demonstrated there was considerable cytotoxicity against human colon cells associated with CMC/baclofen-HKUST-1 bio-nanocomposite. According to the findings of CMC/baclofen-HKUST-1 bio-nanocomposite assessments, the mentioned component could be applied to drug administration.

Keywords: Baclofen; HKUST-1; Carboxymethyl cellulose; Bio-nanocomposite; Drug delivery

Full paper is available at www.springerlink.com.

DOI: 10.1007/s11696-022-02348-0

 

Chemical Papers 76 (10) 6557–6566 (2022)

Tuesday, April 16, 2024

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