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Ruthenium-catalyzed regioselective N-directed C–H olefination of 2-phenylphthalazinone

Minoo Dabiri and Seyed Iman Alavioon

Department of Organic Chemistry and Oil, Faculty of Chemistry and Petroleum Sciences, Shahid Beheshti University, Tehran, Iran

 

E-mail: m-dabiri@sbu.ac.ir

Received: 27 October 2021  Accepted: 10 April 2022

Abstract:

The 2-phenylphthalazinone derivatives are the main skeleton of various pharmaceuticals. In this work, an efficient method for the regioselective Ru(II)-organometallic complex-catalyzed alkenylation of 2-phenylphthalazinone through N-directing group via C–H activation process is presented. The results have proved to be satisfactory for a wide range of yields bearing an electron-donating and electron-withdrawing groups on substrates.

Graphical abstract

Keywords: Organometallic complex; 2-Phenylphthalazinone; Directing group; C–H activation

Full paper is available at www.springerlink.com.

DOI: 10.1007/s11696-022-02221-0

 

Chemical Papers 76 (9) 5523–5532 (2022)

Sunday, June 23, 2024

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