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Cu(II), Co(II), Ni(II), Zn(II) and Cd(II) complexes of novel azo ligand 6-hydroxy-4 methyl-2 oxo-5-[(4,5,6,7-tetrahydro-1,3-benzothiazol-2-yl)diazenyl]-1,2-dihydropyridine 3-carbonitrile as potential biological agents: synthesis and spectroscopic characterization

M. R. Maliyappa and J. Keshavayya

Department of PG Studies and Research in Chemistry, Kuvempu University, Shivamogga, India



Received: 27 August 2021  Accepted: 26 January 2022


A series of metal [Cu(II), Co(II), Ni(II), Zn(II) and Cd(II)] complexes have been prepared by a novel azo ligand, 6-hydroxy-4 methyl-2-oxo-5-[(4,5,6,7-tetrahydro-1,3-benzothiazol-2-yl)diazenyl]-1,2-dihydropyridine-3-carbonitrile [HL] derived from pyridone moiety. Newly prepared complexes were confirmed by investigating various spectroscopic and analytical techniques. The azo ligand [HL] and its metal complexes have been explored for their biological studies such as DPPH (2,2-diphenyl-1-picrylhydrazyl) and anticancer. All the prepared compounds exhibited significant DPPH radical scavenging results compared with the standard ascorbic acid. In addition, tested compounds showed moderate to good anticancer activity against A549, Jurkat and K562 cell lines.

Graphical abstract

Keywords: Metal complex; Azo dye; Benzothiazole; Pyrazole; Anticancer

Full paper is available at

DOI: 10.1007/s11696-022-02101-7


Chemical Papers 76 (6) 3485–3498 (2022)

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