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Molecularly imprinted mesoporous silica: potential of the materials, synthesis and application in the active compound separation from natural product

Kevin Reinard Lie, Amabel Odelia Samuel, and Aliya Nur Hasanah

Department of Pharmaceutical Analysis and Medicinal Chemistry, Faculty of Pharmacy, Universitas Padjadjaran, Sumedang, Indonesia



Received: 8 July 2021  Accepted: 8 January 2022


The availability of active compounds is quite low, and a long extraction and isolation process is required. Mesoporous silica nanoparticles (MSNs) are promising materials with varying pore sizes and a large surface area that can be used for the extraction, isolation, and separation of active compounds from natural products. Molecularly imprinted mesoporous silica (MIP-MS), which is the combination of molecularly imprinted polymers (MIPs) and MSNs, exhibits some benefits such as improved binding capacity, reduced equilibrium time, high surface-to-volume ratio, and also good selectivity. The adsorption capacity of MIP-MS ranges from 11.9–45.31 mg/g, the imprinting factor ranges from 1.87–1.95, and the efficiency exceeds 90% after six repetitions. These properties are ideal for the isolation or separation of active compounds from natural products. This review aims to discover the potential of MIP-MS for the separation of active compounds from natural products, which is currently limited by the source of knowledge but has a great potential for its implementation. In this review, the essentials of MIP-MS, such as the synthesis methods of mesoporous silica, the application of mesoporous silica on MIPs for natural products, and the advantages of MIP-MS, will be discussed.

Keywords: Mesoporous silica nanoparticles; Molecularly imprinted polymers; Molecularly imprinted mesoporous silica; Natural products

Full paper is available at

DOI: 10.1007/s11696-022-02074-7


Chemical Papers 76 (5) 2595–2613 (2022)

Tuesday, June 18, 2024

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