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Influence of mono- and two-component organic modifiers on determination of lipophilicity of tetradentate Schiff bases

Nikola Stevanović, Aleksandar Mijatović, Aleksandar Lolić, Mario Zlatović, and Rada Baošić

Analysis, Belgrade, Serbia



Received: 7 May 2021  Accepted: 17 September 2021


The influences of the application of mono- and two-component organic modifiers on lipophilicity determination of 12 tetradentate Schiff bases by reversed-phase thin layer chromatography were investigated. The main goal is to estimate types of interaction between observed compounds and components of the applied chromatographic systems and establish some behaviour pattern in order to easier choose a combination of organic modifiers which will simulate interaction in biological systems based on the facts that the same basic intermolecular interactions are responsible for the behaviour of substances in both the biological and chromatographic system. The applied organic modifier shows the ability to modify the surface of the applied sorbent, which affects the manifestation of lipophilicity of the observed compounds. Mono-component organic modifiers from different groups of the Snyder triangle were used, as well as their two-component mixtures. In addition, we compared experimentally determined calculated parameters of lipophilicity.

Keywords: Schiff base; Lipophilicity; RP-TLC; Organic modifiers

Full paper is available at

DOI: 10.1007/s11696-021-01884-5


Chemical Papers 76 (1) 585–593 (2022)

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