ISSN print edition: 0366-6352
ISSN electronic edition: 1336-9075
Registr. No.: MK SR 9/7

Published monthly

The interaction and energetics of the mixture of SDS and paracetamol in presence of zinc sulfate in an aqueous media

Sharmin Sultana Rakhi, Shurid Kishore Mahalanobish, Md. Ruhul Amin, Mohammad Robel Molla, Shamim Mahbub, Malik Abdul Rub, Md. Anamul Hoque, Maha Moteb Alotaibi, and Abdullah M. Asiri

Department of Chemistry and Physics, Gono Bishwabidyalay, Savar, Bangladesh



Received: 12 June 2021  Accepted: 22 August 2021


Paracetamol (PCM) is one of the most commonly employed drugs for the treatment of fever and pain. The activity of the drug is dependent on the excipients utilized during formulation as well as on physiological conditions. Herein, the conductivity measurements are implied to deduce the possible molecular interactions occurring between sodium dodecyl sulfate (SDS) and PCM in the presence of ZnSO4 at various temperatures. The critical micelle concentration (cmc) of SDS was found to be lowered with the augmentation of PCM concentration. The cmc values of the SDS + PCM mixture were found to be reduced with the increase of temperature and concentration of ZnSO4. The counterion binding values were found to be temperature and additives dependent. The estimated values of free energies of micellization (\(\Delta G_{m}^{o}\)) signify the spontaneous aggregation of SDS + PCM mixture in all media studied. The spontaneity of self-assembly for SDS + PCM mixture augmented at a higher temperature. The estimated values of enthalpy of micellization (\(\Delta H_{m}^{o}\)) and entropy of micellization (\(\Delta S_{m}^{o}\)) were positive throughout. The values of \(\Delta H_{m}^{o}\) and \(\Delta S_{m}^{o}\) exhibit excellent linearity. The values of different transfer energies, intrinsic enthalpies, and compensation temperature were also calculated and explained properly.

Keywords: Paracetamol; Surfactant; Self-assembly; Conductivity measurement; Zinc sulfate; Thermodynamics

Full paper is available at

DOI: 10.1007/s11696-021-01836-z


Chemical Papers 76 (1) 179–188 (2022)

Monday, June 24, 2024

SCImago Journal Rank 2021
European Symposium on Analytical Spectrometry ESAS 2022
© 2024 Chemical Papers