ISSN print edition: 0366-6352 ISSN electronic edition: 1336-9075 Registr. No.: MK SR 9/7 Published monthly

A novel synthesis of isothiocyanates from amines and phenyl isothiocyanate via replacement reaction

Shou-ji Zhu and Jin-feng Li

Guangdong Province, College of Chemical and Environmental Engineering, Hanshan Normal University, Chaozhou, China

E-mail: zsj82633829@126.com

Received: 5 March 2021  Accepted: 30 April 2021

Abstract:

A new efficient method for the synthesis of isothiocyanates has been developed via the replacement reaction of phenyl isothiocyanate and the corresponding amines (the amino group of these amines was linked to tertiary carbon or secondary carbon) with dimethylbenzene as solvent. This reaction was carried out under the protection of nitrogen and mild condition. In addition, the yields of some products could be more than 90%. More importantly, this method has advantages with low toxicity, low cost, safety, less by-products and simple to operate. It has the potential to realize the industrial production of some complicated isothiocyanates.

Keywords: Isothiocyanates; Phenyl isothiocyanate; Amines; Replacement reaction; One-pot synthesis

Full paper is available at www.springerlink.com.

DOI: 10.1007/s11696-021-01692-x

Chemical Papers 75 (9) 4543–4547 (2021)