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Efficient Au nanostructures for NIR-responsive controlled drug delivery systems

Maria Zafar, Mohsin Ijaz, and Tahir Iqbal

Department of Physics, Faculty of Sciences, University of Gujrat, Hafiz Hayat Campus, Gujrat, Pakistan



Received: 16 July 2020  Accepted: 8 December 2020


Different photo-thermal agents such as gold nanostructures with various shapes and sizes including nano-rods, nano-cages, nano-shells exhibit tunable optical properties, surface chemistry, resonance frequency and non-toxicity. Furthermore, gold nanoparticles (Au NPs) also utilized for diagnosis purposes and drug carriers for thermo-therapy of biological cells targets and potential bio-medical applications against various cancer treatments. To control complications of conventional cancer therapeutics, Stimuli-assisted drug delivery systems (DDS) together with interior and exterior Stimuli-assisted prompts have received particular interest by the scientific community around the globe. Among both of them, external stimuli-responsive parameters provide more controlled DDSs that circumvent individual discrepancy. Many researchers reported that light-responsive DDSs manifest interesting features because of proficiency and preferable spatiotemporal control. Among them, near-infrared light-responsive DDSs are potential candidates that follow various mechanisms such as photo-thermal effect, two photon absorption, and up converting nano-particles. This review presents an over view of different morphologies of Au nanostructures boosting the efficiency of DDSs by utilizing the phenomenon of surface plasmon resonance by overcoming the major challenges.

Keywords: Au plasmonics; Stimuli-responsive drug delivery systems; Spatiotemporal control; Photo-thermal; Cancer treatments

Full paper is available at

DOI: 10.1007/s11696-020-01465-y


Chemical Papers 75 (6) 2277–2293 (2021)

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