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Micronization and characterization of ultrafine pure and composite aspirin by CO2-expanded solution

Hossein Rostamian, Mohammad Nader Lotfollahi, and Ali Mohammadi

Faculty of Chemical, Petroleum and Gas Engineering, Semnan University, Semnan, Iran



Received: 5 March 2020  Accepted: 9 July 2020


The objective of this work is to enhance the dissolution rate of a poorly water-soluble drug, aspirin, by production of micronized aspirin and aspirin/polyethylene glycol 4000 (aspirin/PEG4000) composite with pressure reduction of gas-expanded solution (PPRGEL) method. The obtained particles were characterized by X-ray diffraction (XRD), scanning electron microscopy (SEM), differential scanning calorimetry (DSC) and Fourier-transform infrared spectroscopy (FTIR) analysis. Influence of different operating parameters (pressure, temperature, concentration) and solvent type on morphology and average size of products were investigated. It was found that the used technique decreases the mean size of the aspirin particles from 465 to 5.8 μm. The dissolution rate of the aspirin-PEG4000 composite was also studied. It was found that ~ 80% of aspirin in the composite was dissolved within the first 9.5 min of the dissolution process, while it was up to 60 min for the unprocessed aspirin.

Keywords: Aspirin; Co-precipitation; PEG4000; Carbon dioxide; Micronization

Full paper is available at

DOI: 10.1007/s11696-020-01283-2


Chemical Papers 75 (1) 99–113 (2021)

Wednesday, April 24, 2024

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