ISSN print edition: 0366-6352 ISSN electronic edition: 1336-9075 Registr. No.: MK SR 9/7 Published monthly

Synthesis and biological properties of silicon(IV) phthalocyanine with bis-(2-(vinyloxy)ethoxy) substitution

Gökhan Turan, Derya Güngördü Solğun, Sadin Özdemir, Serpil Gonca, and Mehmet Salih Ağırtaş

Department of Chemistry, Faculty of Science, Van Yuzuncu Yıl University, Van, Turkey

E-mail: agirtas65@yyu.edu.tr

Received: 30 October 2025  Accepted: 16 March 2026

Abstract:

Here, a new axial phthalocyanine was synthesized and characterized. Research on its biological properties provides reasonable data, which indicates that it can be used in areas where it is needed. The antioxidant activity of the phthalocyanine compound was evaluated using the 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging assay, and the results indicated that phthalocyanine compound exhibited antioxidant activity. The α-amylase inhibitory activity reached up to 96.54 ± 4.96% at a concentration of 100 mg/L, indicating strong antidiabetic potential. The DNA cleavage ability of the phthalocyanine compound was assessed using gel electrophoresis, which revealed complete cleavage of the pBR322 plasmid DNA. The antimicrobial activity of the phthalocyanine was determined using the microdilution method (MIC). According to the MIC results, phthalocyanine compound exhibited antibacterial activity. The biofilm inhibition properties of phthalocyanine was also investigated against Staphylococcus aureus and Pseudomonas aeruginosa. The results indicated that P. aeruginosa was more susceptible to the compound than S. aureus. Additionally, the antibiofilm activity of the phthalocyanine compounds was evaluated under antimicrobial photodynamic therapy (aPDT) conditions. At a concentration of 25 mg/L, phthalocyanine compound inhibited biofilm formation by 93.29 ± 4.71% and 99.27 ± 5.39% against S. aureus and P. aeruginosa, respectively. Furthermore, at a concentration of 25 mg/L, phthalocyanine compound achieved 100 ± 5.52% inhibition of Escherichia coli viability. The biological parameters examined indicate that this substance has potential for medical use.

Keywords: Biofilm inhibition; Cell viability; Antioxidant; Antimicrobial; Phthalocyanine; aPDT

Full paper is available at www.springerlink.com.

DOI: 10.1007/s11696-026-04816-3

Chemical Papers 80 (6) 7043–7057 (2026)