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Sedative effects of diphenylimidazolidine derivatives

L. Molnár, F. Selecký, and J. Tamchyna

Research Institute for Pharmacy and Biochemistry, Bratislava

 

Abstract: Sedative effects of diphenylimidazolidine derivs. (I) of the type, NR.C(:O).CPh2.NR'2.C:O(S), were studied on rats by using a new very exact method, permitting a large mobility record on a very large no. of exptl. animals. The analgesic effects by elec. irritations and the anticonvulsive effects were also tested. For therapeutic use the best was 2-thio-5-oxo-4,4-diphenylimidazolidine (II), which was almost nontoxic, without hypnotic effect, and in analgesic effects comparable with aminopyrine. I did not increase fatigue as phenylethylbarbituric acid, but if I were used in larger amts. the agility of animals was increased. From the galenic standpoint II can be mixed with amidopyrine, phenacetin, and caffeine.

Full paper in Portable Document Format: 71-2a107.pdf (in Slovak)

 

Chemical Papers 7 (1-2) 107–128 (1953)

Monday, May 27, 2024

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