Synthesis, characterization, and anti-tumor activities of some transition metal(II) complexes with podophyllic acid hydrazide
Jian-Qiang Qu, Ling Qu, Qiu-Hua Yang, and Liu-Fang Wang
Department of Chemistry, School of Science, Tianjin University, Tianjin, 300072, China
Received: 7 July 2008 Revised: 11 November 2008 Accepted: 18 November 2008
Abstract: Four transition metal(II) complexes with podophyllic acid hydrazide (HL) were prepared and characterized by elemental analysis,
complexometric titration, thermal analysis, conductivity, IR, and 1H NMR. The complexes have the general formula ML2 · nH2O, where M = Zn, Cu, Co, and Ni, n = 2 or 0. Anti-tumor activities of podophyllotoxin, HL, ZnL2 · 2H2O, and NiL2 were tested by both the MTT and the SRB method. The results show that the activities of the complexes against the tumor cells
tested are superior to HL and the anti-tumor activity of NiL2 is even similar to that of podophyllotoxin.
Keywords: transition metal - complexes - podophyllic acid hydrazide - anti-tumor activities
Full paper is available at www.springerlink.com and www.degruyter.com.
Chemical Papers 63 (4) 426–431 (2009)