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Influence of Structure on Antimicrobial Activity of Some Heterocycles.3 . 1-Substituted 2-Methyl-5-nitroimidazoles

M. Koóš, Z. Novotná, and A. Rybár

Institute of Chemistry, Slovak Academy of Sciences, SK-842 38 Bratislava

 

Abstract: Several 1-(3-alkyl- resp. 3-arylthio-2-hydroxypropyl)-2-methyl-5-nitroimidazoles were prepared starting from ornidazole. Some sulfones as well as sulfoxides were obtained by oxidation of corresponding sulfides by hydrogen peroxide. The structure of the prepared compounds was confirmed on the basis of IR, mass, NMR spectral data and elemental analysis. Antimicrobial activity of these compounds was also determined. No significant results were found in this respect.

Full paper in Portable Document Format: 481a50.pdf

 

Chemical Papers 48 (1) 50–54 (1994)

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