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One-pot, three-component synthesis of secondary amines and trisubstituted hydrazines from ketones

H. Tavakol and S. Zakery

Department of Chemistry, Faculty of Sciences, Zabol University, Zabol, Iran



Received: 3 November 2005  Revised: 17 February 2006  Accepted: 25 February 2006

Abstract: Various imines and hydrazones were reduced to the corresponding amines and hydrazines using borane-tetrahydrofuran complex as a reducing agent in the solution of lithium perchlorate in diethyl ether. The initial imines or hydrazones have been prepared at the same conditions just before the reduction step. Both steps were carried out in one vessel with a good yield and insignificant formation of by-products.

Keywords: one-pot synthesis - secondary amines - trisubstituted hydrazines - reductive amination - ketones

Full paper is available at and

DOI: 10.2478/s11696-006-0056-2


Chemical Papers 60 (4) 315–317 (2006)

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